Project Title: The effects of Tuberculosis on dietary iron absorption and systemic iron utilization. A double stable isotope study in Bagamoyo
Project Description: The disease burden of tuberculosis (TB) is a major public health problem in developing countries. Accumulating evidence suggests that iron status in primary determinant of TB progression and anemia is prevalent in patients with TB, particularly in sub-Saharan Africa, and associated with increased mortality. Thus, a better understanding of iron metabolism during TB and the aetiology of TB-related anaemia would clarify the potential role of iron in pathogenesis and optimal management of the disease. Stable... The disease burden of tuberculosis (TB) is a major public health problem in developing countries. Accumulating evidence suggests that iron status in primary determinant of TB progression and anemia is prevalent in patients with TB, particularly in sub-Saharan Africa, and associated with increased mortality. Thus, a better understanding of iron metabolism during TB and the aetiology of TB-related anaemia would clarify the potential role of iron in pathogenesis and optimal management of the disease. Stable Iron isotopes will be used to characterize iron balance over TB treatment, and specifically to a quantify oral and intravenous iron incorporation (Oral absorption and systemic iron utilization) during TB treatment phase), and b) determine the effect of treatment on iron mobilization from stores to replenish haemoglobin. Iron absorption from labelled test meals (57Fe) and systemic iron utilization after labelled intravenous doses (54Fe, 58Fe) will be determined in 18 Tanzanian subjects with newly diagnosed pulmonary TB. The subjects will be studied the day after TB diagnosis while infected and during treatment. Iron status, hemoglobin, hepcidin and inflammation indexes will be measured at each time point. The project will provide important new insights into the aetiology of anaemia and iron metabolism in TB patients. The results will provide essential data for evidence-based recommendations on the timing, administration route and efficacy of iron therapy in patients with TB, making possible, a safer and more effective treatment of anaemia in Tb while decreasing morbidity and mortality from the disease.
Principal Investigator : Francis Mhimbira
Department Name : BRCT
Time frame: (2015-01-01) - (2017-01-31)
ETH Zurich (Normal)
External Collaborating Partners
None added yet.